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Fibrinogen is a protein made by the liver that helps your blood clot when you are injured. It is also an acute-phase protein, meaning its levels increase when the body is experiencing inflammation. Because fibrinogen participates in both clotting and inflammatory processes, it can rise when the immune system is activated.
Higher fibrinogen levels are associated with systemic inflammation and increased cardiovascular risk. Elevated levels have been linked to conditions such as heart disease, stroke, metabolic dysfunction, and chronic inflammatory states. Fibrinogen is therefore a useful complementary marker when evaluating overall inflammatory burden alongside other markers such as hsCRP.
Higher fibrinogen levels may reflect chronic inflammation, cardiovascular risk, infection, smoking, obesity, or metabolic dysfunction. Very high levels can occur during acute inflammatory states.
Fibrinogen Studies Collaboration, Kaptoge, S., White, I. R., Thompson, S. G., Wood, A. M., Lewington, S., Lowe, G. D. O., & Danesh, J. (2007). Associations of plasma fibrinogen levels with established cardiovascular disease risk factors, inflammatory markers, and other characteristics: individual participant meta-analysis of 154,211 adults in 31 prospective studies: the fibrinogen studies collaboration. American Journal of Epidemiology, 166(8), 867–879. https://doi.org/10.1093/aje/kwm191
Luyendyk, J. P., Schoenecker, J. G., & Flick, M. J. (2019). The multifaceted role of fibrinogen in tissue injury and inflammation. Blood, 133(6), 511–520. https://doi.org/10.1182/blood-2018-07-818211
This information is educational and does not replace medical advice, diagnosis, or treatment. Your results should be interpreted with a qualified healthcare professional in the context of your health history.